|
|
Raphael Levine
|
Professor,
Chemistry and Biochemistry,
Physical Chemistry
|
Work Email Address:
rafi@chem.ucla.edu
Work Address:
Geology 3608A
Phone Numbers:
1 (310) 206-0476
|
Research Interest:
Towards theoretical systems biology and a system view of medicine we seek to provide a description of molecular -e.g., kinase-signaling networks that is intermediate between biochemical components and a global view and that highlights predictive ability. It is desired to present not only a steady state but also a time evolving portrayal of the network
dynamics. The approach inherently allows for the inevitable cellular fluctuations and offers different levels of coarse graining -e.g., proteins, pathways, networks - of the description. At each level we provide the minimal set of informative constraints that recover the state of the components. Such quantitative insight into the state of diseased cells is intended to aid the development of effective diagnostics and tailored intervention. As a practical consideration, the input takes advantage of the large volumes of data produced by the current methods of systems biology. A secondary objective of our program is the use of signal transduction networks as models for robust and error correcting concatenated
logic networks.
|
Selected Publications:
Klein, M. Lansbergen, G. P. Mol, J. A. Rogge, S. Levine, R. D. Remacle, F. Reconfigurable Logic Devices on a Single Dopant Atom-Operation up to a Full Adder by Using Electrical Spectroscopy.
Chemphyschem.
2009;
10( 1):
162-173.
Kuznetz, O. Salman, H. Eichen, Y. Remacle, F. Levine, R. D. Speiser, S. All optical full adder based on intramolecular electronic energy transfer in the rhodamine-azulene bichromophoric system.
Journal of Physical Chemistry C.
2008;
112( 40):
15880-15885.
Torres, E. A. Kompa, K. L. Remacle, F. Levine, R. D. Ultrafast vibrational spectroscopy and relaxation in polyatomic molecules: Potential for molecular parallel computing.
Chemical Physics.
2008;
347( 1-3):
531-545.
Remacle, F. Kienberger, R. Krausz, F. Levine, R. D. On the feasibility of an ultrafast purely electronic reorganization in lithium hydride.
Chemical Physics.
2007;
338( 2-3):
342-347.
Remacle, F. Levine, R. D. Time-resolved electrochemical spectroscopy of charge migration in molecular wires: Computational evidence for rich electronic dynamics.
Journal of Physical Chemistry C.
2007;
111( 5):
2301-2309.
Remacle, F. Levine, R. D. Towards parallel computing: representation of a linear finite state digital logic machine by a molecular relaxation process.
European Physical Journal D.
2007;
42( 1):
49-59.
Klein, M. Rogge, S. Remacle, F. Levine, R. D. Transcending binary logic by gating three coupled quantum dots.
Nano Letters.
2007;
7( 9):
2795-2799.
Gross, A. Levine, R. D. A mechanical representation of entropy for a large finite system.
Journal of Chemical Physics.
2006;
125( 14):
9.
Gross, A. Levine, R. D. Mechanical simulation of the pressure and the relaxation to thermal equilibrium of a hot and dense rare gas cluster.
Journal of Physical Chemistry B.
2006;
110( 47):
24070-24076.
Kornweitz, H. Gross, A. Birnbaum, G. Levine, R. D. Probing electronic rearrangement during chemical reactions.
PHYSICA SCRIPTA
2006;
73(1):
C1-C5.
Remacle, F. Levine, R. D. The time scale for electronic reorganization upon sudden ionization of the water and water-methanol hydrogen bonded dimers and of the weakly bound NO dimer.
Journal of Chemical Physics.
2006;
125( 13):
7.
Gross, A. Levine, R. D. Evanescent high pressure during hypersonic cluster-surface impact characterized by the virial theorem.
Journal of Chemical Physics.
2005;
123( 19):
11.
Somorjai, G. A. Levine, R. D. The changing landscape of physical chemistry at the beginning of the 21st century.
Journal of Physical Chemistry B.
2005;
109( 19):
9853-9854.
Remacle, F. Levine, R. D. Electrical transmission of molecular bridges.
Chemical Physics Letters.
2004;
383( 5-6):
537-543.
Remacle, F. Levine, R. D. Electronic and electrical response of arrays of metallic quantum dots.
secondary-title.
2004;
volume(number):
743-751.
Gross, A. Kjellberg, M. Levine, R. D. Systematics of collision-induced light emission from hot matter.
Journal of Physical Chemistry A.
2004;
108( 41):
8949-8953.
Gross, A. Levine, R. D. Collision-induced IR emission spectra of impact-heated rare-gas clusters.
Journal of Physical Chemistry A.
2003;
107( 45):
9567-9574.
Torres, E. A. Baugh, D. A. Levine, R. D. Ultra-short time resolution from energy-dependent interference of photodissociation amplitudes.
Chemical Physics Letters.
2003;
375( 1-2):
141-148.
Remacle, F. Levine, R. D. Voltage-induced phase transition in arrays of metallic nanodots: Computed transport and surface potential structure.
Applied Physics Letters.
2003;
82( 25):
4543-4545.
Campbell, E. E. B. Glotov, A. V. Lassesson, A. Levine, R. D. Cluster-cluster fusion.
Comptes Rendus Physique.
2002;
3( 3):
341-352.
Remacle, F. Weinkauf, R. Steinitz, D. Kompa, K. L. Levine, R. D. Molecular logic by optical spectroscopy with output transfer by charge migration along a peptide.
Chemical Physics.
2002;
281( 2-3):
363-372.
Wang, J. X. Kais, S. Remacle, F. Levine, R. D. Size effects in the electronic properties of finite arrays of exchange-coupled quantum dots.
Journal of Physical Chemistry B.
2002;
106( 50):
12847-12850.
Remacle, F. Levine, R. D. Voltage-induced nonlinear characteristics of arrays of metallic quantum dots.
Nano Letters.
2002;
2( 7):
697-701.
|
|
