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Huiying Li
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Assistant Professor,
Molecular & Medical Pharmacology
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Faculty,
Crump Institute for Molecular Imaging
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Email Address:
huiying@mednet.ucla.edu
Home Page:
http://labs.pharmacology.ucla.edu/lilab/
Department Address:
Crump Institute for Molecular Imaging
Laboratory Address:
CNSI 4338
Office Address:
CNSI 4339
Phone Numbers:
(310) 983-3212
Lab
Phone Numbers:
(310) 206-5585
Office
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Research Interest:
My research interest is to understand the gene regulation and protein interaction networks in organisms at a systems level. I have previously applied bioinformatics, X-ray crystallography and gene expression profiling to study protein functions and interactions in metabolism and infectious diseases. My current research focuses on understanding the human microbiome (the collective genome of trillions of microorganisms in human microflora) and its interactions with the host in relation to human health and diseases. Using a systems biology approach, including high-throughput genome sequencing, metagenomic microarrays and computational modeling, the aim of the research is to detect signature microflora patterns and to develop diagnostic markers and therapeutics for microorganism-related human diseases. By combining computational and experimental approaches, the ultimate goal of my research is to understand the human-microflora symbiotic system at both molecular level and systems level.
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Selected Publications:
Tabita, F. R. Hanson, T. E. Li, H. Satagopan S. Singh J. Chan S. Function, structure, and evolution of the RubisCO-like proteins and their RubisCO Homologs.
Microbiology and Molecular Biology Reviews.
2007;
71(4):
576-599.
Yooseph, S. ..., Li, H. et al. The Sorcerer II Global Ocean Sampling Expedition: Expanding the Universe of Protein Families.
PLoS Biol.
2007;
5(3):
e16.
Liu, P. T.* Stenger, S.* Li, H. Wenzel, L. Tan, B. H. Krutzik, S. R. Ochoa, M. T. Schauber, J. Wu, K. Meinken, C. Kamen, D. L. Wagner, M. Bals, R. Steinmeyer, A. Zugel, U. Gallo, R. L. Eisenberg, D. Hewison, M. Hollis, B. W. Adams, J. S. Bloom, B. R. Modlin, R. L. Toll-like receptor triggering of a vitamin D-mediated human antimicrobial response.
Science.
2006;
311(5768):
1770-3. (*equal contribution).
Krutzik, S. R. Tan, B. Li, H. Ochoa, M. T. Liu, P. T. Sharfstein, S. E. Graeber, T. G. Sieling, P. A. Liu, Y. J. Rea, T. H. Bloom, B. R. Modlin, R. L. TLR activation triggers the rapid differentiation of monocytes into macrophages and dendritic cells.
Nat Med.
2005;
11(6):
653-60.
Li, H. Sawaya, M. R. Tabita, F. R. Eisenberg, D. Crystal structure of a RuBisCO-like protein from the green sulfur bacterium Chlorobium tepidum.
Structure (Camb).
2005;
13(5):
779-89.
Li, H. Pellegrini, M. Eisenberg, D. Detection of parallel functional modules by comparative analysis of genome sequences.
Nat Biotechnol.
2005;
23(2):
253-60.
Bleharski, J. R.* Li, H.* Meinken, C.* Graeber, T. G.* Ochoa, M. T. Yamamura, M. Burdick, A. Sarno, E. N. Wagner, M. Rollinghoff, M. Rea, T. H. Colonna, M. Stenger, S. Bloom, B. R. Eisenberg, D. Modlin, R. L. Use of genetic profiling in leprosy to discriminate clinical forms of the disease.
Science.
2003;
301(5639):
1527-30. (*equal contribution).
Li, H. Guo, Z. F. Zhu, Y. X. Molecular cloning and analysis of a pea cDNA that is expressed in darkness and very rapidly induced by gibberellic acid.
Mol Gen Genet.
1998;
259(4):
393-7.
Zhu, Y. Zhang, Y. Li, H. Molecular cloning of GA-suppressed G2 pea genes by cDNA RDA.
Science in China, Series C
1997;
40:
379-83.
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