Sung-Cheng (Henry) Huang
Professor, Molecular & Medical Pharmacology
Member, ACCESS Program: Dept. of Molecular & Medical Pharmacology, Cancer Molecular Imaging, DOE Funded Faculty
Faculty, Crump Institute for Molecular Imaging

Methodologies to extract quantitative biological information from kinetic radioactivity measurements from various imaging devices

Email Address:  hhuang@mednet.ucla.edu

Work Address:
CHS
CHS


Phone Numbers:
310-825-4517 Phone Numbers:
310-794-6675 Laboratory
310-825-6647 Office


Selected Publications:

Huang, SC Wu, HM Shoghi-Jadid, K Stout, DB Chatziioannou, A Schelbert, HR Barrio, JR Investigation of a new input function validation approach for dynamic mouse microPET studies.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. . 2004; 6(1): 34-46.
Wu, H.M., Huang, S.C.,Hattori, N., Glenn, T.C., Vespa, P.M., Hovda, D.A., Bergsneider, M. Subcortical white matter metabolic changes remote from focal hemorrhagic lesions suggest diffuse injury following human traumatic brain injury (TBI). Neurosurgery 2004; 55(6): 1306-1317.
Agdeppa, ED Kepe, V Liu, J Small, GW Huang, SC Petric, A Satyamurthy, N Barrio, JR 2-Dialkylamino-6-acylmalononitrile substituted naphthalenes (DDNP analogs): novel diagnostic and therapeutic tools in Alzheimer's disease.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. . 2003; 5(6): 404-17.
Agdeppa ED, Kepe V, Petri A, Satyamurthy N, Liu J, Huang SC, Small GW, Cole GM, Barrio JR. In vitro detection of (S)-naproxen and ibuprofen binding to plaques in the Alzheimer's brain using the positron emission tomography molecular imaging probe 2-(1-[6-[(2-[(18)F]fluoroethyl)(methyl)amino]-2-naphthyl]ethylidene)malononitrile.. Neuroscience. 2003; 117(3):: 723-30.
Wu HM, Bergsneider M, Glenn TC, Yeh E, Hovda DA, Phelps ME, Huang SC. Measurement of the global lumped constant for 2-deoxy-2-[18F]fluoro-D-glucose in normal human brain using [15O]water and 2-deoxy-2-[18F]fluoro-D-glucose positron emission tomography imaging. A method with validation based on multiple methodologies.. Mol Imaging Biol. 2003; 5(1):: 32-41.
Hattori, N Huang, SC Wu, HM Liao, W Glenn, TC Vespa, PM Phelps, ME Hovda, DA Bergsneider, M PET investigation of post-traumatic cerebral blood volume and blood flow.. Acta neurochirurgica. Supplement. . 2003; 86: 49-52.
Zhou Y, Huang SC, Bergsneider M, Wong DF Improved parametric image generation using spatial-temporal analysis of dynamic PET studies, Neuroimaging.. 2002; 15: 697-707.
Shoghi-Jadid K, Small GW, Agdeppa ED, Kepe V, Ercoli LM, Siddarth P, Read S, Satyamurthy N, Petric A, Huang SC, Barrio JR Localization of Neurofibrillary Tangles (NFTs) and Beta-Amyloid Plaques (APs) in the Brains of Living Patients with Alzheimer?s Disease.. Am J. Geriatric Psychiatry 2002; 10: 24-35.
Kudo T, Fukuchi K, Annala AJ, Chatziioannou AF, Allada V, Dahlbom M, Tai YC, Inubushi M, Huang SC, Cherry SR, Phelps ME, Schelbert HR. Noninvasive measurement of myocardial activity concentrations and perfusion defect sizes in rats with a new small-animal positron emission tomograph.. Circulation 2002; 106(1):: 118-23.
Huang SC Anatomy of SUV (Standardized Uptake Value).. Nuclear Medicine & Biology 2000; 27: 643-646.
Shoghi-Jadid K, Huang SC, Stout DB, Yee RE, Yeh EL, Farahani KF, Satyamurthy N, Phelps ME, Barrio JR Striatal kinetic modeling of FDOPA with a cerebellar-derived constraint on the distribution volume of 3OMFD: a positron emission tomography (PET) investigation using non-human primates.. J. Cereb. Blood Flow Metab 2000; 20: 1134-1148.
Huang SC Image oscillation reduction and convergence acceleration for OS-EM reconstruction.. IEEE Trans. Nucl. Sci 1999; 46: 607-607.
Choi Y, Huang SC, Hawkins RA, Kim JY, Kim BT, Hoh CK, Chen K, Phelps ME, Schelbert HR Quantification of myocardial blood flow using N-13 ammonia and PET: comparison of tracer methods.. J. Nucl. Med. 1999; 40: 1045-1055.
Huang SC, Quintana J, Satyamurthy N, Lacan G, Yu DC, Phelps ME, Barrio JR [F-18]fluoro-b-fluoromethylene-m-tyrosine derivatives show stereo-,geometric and regio specificity as in-vivo central dopaminergic probes in monkeys.. Nucl Med and Biol 1999; 26: 365-370.
Huang, Sung-Cheng, Zhou, Yun Spatially-coordinated regression for image-wise model fitting to dynamic PET data for generating parametric images... IEEE Transactions on Nuclear Science 1998; 45: 1194-1199.
Yang, J., Huang, S.C., Mega, M., Lin, K.P., Toga, A.W., Small, G.W., Phelps, M.E. Investigation of partial volume correction methods for brain FDG PET studies. (fluorodeoxyglucose; positron emission tomography).. IEEE Transactions on Nuclear Science 1996; 43: 3322-3327.
Wu, HM Huang, SC Hattori, N Glenn, TC Vespa, PM Yu, CL Hovda, DA Phelps, ME Bergsneider, M Selective metabolic reduction in gray matter acutely following human traumatic brain injury.. Journal of neurotrauma. . 2004; 21(2): 149-61.
Hattori, N Huang, SC Wu, HM Yeh, E Glenn, TC Vespa, PM McArthur, D Phelps, ME Hovda, DA Bergsneider, M Correlation of regional metabolic rates of glucose with glasgow coma scale after traumatic brain injury.. Journal of nuclear medicine : official publication, Society of Nuclear Medicine. . 2003; 44(11): 1709-16.
Small, GW Agdeppa, ED Kepe, V Satyamurthy, N Huang, SC Barrio, JR In vivo brain imaging of tangle burden in humans.. Journal of molecular neuroscience : MN. . 2002; 19(3): 323-7.
Yee, RE Huang, SC Togasaki, DM Langston, JW Satyamurthy, N Barrio, JR Imaging and therapeutics: the role of neuronal transport in the regional specificity of L-DOPA accumulation in brain.. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. . 2002; 4(3): 208-18.
Saxena, S Brody, AL Ho, ML Alborzian, S Maidment, KM Zohrabi, N Ho, MK Huang, SC Wu, HM Baxter, LR Differential cerebral metabolic changes with paroxetine treatment of obsessive-compulsive disorder vs major depression.. Archives of general psychiatry. . 2002; 59(3): 250-61.
Bergsneider, M Hovda, DA McArthur, DL Etchepare, M Huang, SC Sehati, N Satz, P Phelps, ME Becker, DP Metabolic recovery following human traumatic brain injury based on FDG-PET: time course and relationship to neurological disability.. The Journal of head trauma rehabilitation. . 2001; 16(2): 135-48.
Small, GW Ercoli, LM Silverman, DH Huang, SC Komo, S Bookheimer, SY Lavretsky, H Miller, K Siddarth, P Rasgon, NL Mazziotta, JC Saxena, S Wu, HM Mega, MS Cummings, JL Saunders, AM Pericak-Vance, MA Roses, AD Barrio, JR Phelps, ME Cerebral metabolic and cognitive decline in persons at genetic risk for Alzheimer's disease.. Proceedings of the National Academy of Sciences of the United States of America. . 2000; 97(11): 6037-42.
Bergsneider, M Hovda, DA Lee, SM Kelly, DF McArthur, DL Vespa, PM Lee, JH Huang, SC Martin, NA Phelps, ME Becker, DP Dissociation of cerebral glucose metabolism and level of consciousness during the period of metabolic depression following human traumatic brain injury.. Journal of neurotrauma. . 2000; 17(5): 389-401.
Yee, RE Huang, SC Stout, DB Irwin, I Shoghi-Jadid, K Togaski, DM DeLanney, LE Langston, JW Satyamurthy, N Farahani, KF Phelps, ME Barrio, JR Nigrostriatal reduction of aromatic L-amino acid decarboxylase activity in MPTP-treated squirrel monkeys: in vivo and in vitro investigations.. Journal of neurochemistry. . 2000; 74(3): 1147-57.
Huang, SC Stout, DB Yee, RE Satyamurthy, N Barrio, JR Distribution volume of radiolabeled large neutral amino acids in brain tissue.. Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism. . 1998; 18(12): 1288-93.
Chinn, G Huang, SC A general class of preconditioners for statistical iterative reconstruction of emission computed tomography.. IEEE transactions on medical imaging. . 1997; 16(1): 1-10.
 Michael E. Phelps, Director  Anna Wu, Co-Director  Arion Chatziioannou   Johannes Czernin  Thomas Graeber   Harvey Herschman  Henry Huang  Raphael Levine  Huiying Li  Caius Radu  Kwang-fu Shen  Nagichettiar Satyamurthy  David Stout  Hyongsok Soh  Hsian-Rong Tseng  Michael Van Dam  Christine Wu
Chatziioannou Lab Graeber Lab Li Lab Radu Lab Soh Lab Stout Lab Tseng Lab Van Dam Lab Wu Lab
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