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R. Michael van Dam
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Assistant Professor,
Crump Institute for Molecular Imaging,
Molecular & Medical Pharmacology
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Member,
ACCESS Program: Dept. of Molecular & Medical Pharmacology,
California NanoSystems Institute
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Email Address:
mvandam@mednet.ucla.edu
Group Home Page Redirect:
http://labs.pharmacology.ucla.edu/vandamlab/
Laboratory Address:
570 Westwood Plaza, Building 114
Office Address:
570 Westwood Plaza, Building 114
Phone Numbers:
310-206-6507
Office
310-794-1731
Lab
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Research Interest:
My group is interested in novel microfluidic technologies and automated systems for solving problems in cancer research and molecular imaging. Currently, we are developing a robust automated microfluidic platform for on-demand multi-step chemical synthesis of radiolabeled imaging probes for positron emission tomography (PET). Our aims are to make a wider variety of probes more readily available to scientists and physicians for research and clinical use, and to facilitate the discovery and optimization of new probes. Other research directions include reconfigurable microfluidic chemistry chips that facilitate process optimization, modular plug-and-play microfluidic components that simplify application development, and cell-based molecular imaging platforms for studying cancer biology and developing diagnostics and therapeutics.
Because we are developing technology tools that we hope can ultimately be used by others and automated, we emphasize issues such as robustness, reliability, manufacturability, and user interface in our approaches. Our work is very multi-disciplinary in nature and we collaborate extensively with others in the Crump Institute.
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Selected Publications:
Olma, S., Liu, K., Chen, Y-C, Tseng, H-R, van Dam, R.M., Shen, C.K-F. Application of a microfluidic mixer for [18F]fluorine labeling of biomolecules for positron emission tomography.
Proceedings of MicroTAS 2008
2008;
604-606.
Liu, K., Chen, Y-C, Tseng, H-R, Shen, C.K-F, van Dam, R.M. Fluid-parameter-independent microfluidic device for reliable generation of multi-component droplets.
Proceedings of MicroTAS 2008
2008;
694-696.
van Dam, R.M., Elizarov, A.M., Ball, E., Shen, C.K-F , Kolb, H., Rolland, J., Diener, L., Williams D., Edgecombe, B., Stephen, T., Heath, J.R. Automated microfluidic chip and system for the synthesis of radiopharmaceuticals on human-dose scales.
Proc. Nanotech 2007.
2007;
3:
300-303.
Maltezos, G., Garcia, E., Hanrahan, G., Gomez, F.A., Vyawahare, S., van Dam, R.M., Chen, Y., Scherer, A. Design and fabrication of chemically robust three-dimensional microfluidic valves.
Lab on a Chip.
2007;
7(9):
1209-1211.
Elizarov, A.M., Kolb, H.C., van Dam, R.M., Heath, J.R., Padgett, H.C., Huang, J., Daridon, A. Coin-shaped reactor in microfluidic devices used for radiopharmaceutical synthesis.
Proc. Nanotech 2006.
2006;
2:
542-545.
Elizarov, A.M., van Dam, R.M., Heath, J.R., Kolb, H.C., Huang, J., Daridon, A. Microfluidic device with coin-shaped reactor for radiopharmaceutical synthesis.
Proc. ACS 2006.
2006;
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Rolland, J.P., van Dam, R.M., Hagberg, E.C., Carter, K.R., Quake, S.R., DeSimone, J. Functional perfluoropolyethers as novel materials for microfluidics and soft lithography.
Polymer Preprints.
2004;
45(2):
106-107.
Rolland, J.P., Zhou, Z., Kelly, J.Y., Denison, G.M., van Dam, R.M., Hagberg, E.C., Carter, K.R., Quake, S.R., DeSimone, J.M Liquid precursors for applications in microfluidics, soft lithography, and fuel cells.
PMSE Preprints.
2004;
91:
254-255.
Rolland, JP Van Dam, RM Schorzman, DA Quake, SR DeSimone, JM Solvent-resistant photocurable liquid fluoropolymers for microfluidic device fabrication [corrected]..
Journal of the American Chemical Society.
2004;
126(8):
2322-3.
Reese, MO van Dam, RM Scherer, A Quake, SR Microfabricated fountain pens for high-density DNA arrays..
Genome research.
2003;
13(10):
2348-52.
van Dam, RM Quake, SR Gene expression analysis with universal n-mer arrays..
Genome research.
2002;
12(1):
145-52.
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