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Hsian-Rong Tseng
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Associate Professor,
Molecular & Medical Pharmacology
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Member,
Cancer Molecular Imaging
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Faculty,
Crump Institute for Molecular Imaging
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Email Address:
hrtseng@mednet.ucla.edu
Home Page:
http://labs.pharmacology.ucla.edu/tsenglab/
Work Address:
CNSI, 570 Westwood Plaza
Phone Numbers:
310-206-8975
Fax
Phone Numbers:
1-310-206 7320
Laboratory
1-310-794 1977
Office
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Research Interest:
Our research interests are to develop microfluidics-based technology platforms and to utilize these technology platforms to address important issues in the fields of molecular imaging, cancer biology and chemistry. In contrast to conventional bench-top setups, microfluidics has been used to manipulate chemical and biological processes on nanoliter (nL) to microliter (mL) scales with the profound advantages of enhanced heat transfer performance, faster diffusion time and reaction kinetics, as well as improved control over experimental conditions. By incorporating integrated microvalves into microfluidic batch systems, the integrated microfluidic platforms enable the execution and automation of multiple, parallel, and/or sequential chemical or biological processes on a single chip under digital control. For the past two years, we have been working with several research groups who have expertise covering molecular imaging, cancer biology, immunology and pathology to develop a variety of functioning microfluidic platforms for applications in three major areas of interest: (i) Development of Molecular Imaging Probes, (ii) Biological Analysis and (iii) Production of Nanostructured Materials. In a boarder playing field, our goal remains the creation of further integrated microfluidic technology platforms for the broader space in chemistry and biology beyond a single functioning platform on a chip. We will compile many different microfluidic platforms to produce a number of game systems: "Let's Play _____", where the blank is "systems biology of disease", "biomarkers", "pharmacology", "biochemical reaction kinetics", "chemistry" and "cancer diagnosis" etc. where execution is rapid and learning curves are steep.
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Selected Publications:
Wang, H. Wang, S. Su, H. Chen, K. J. Armijo, A. L. Lin, W. Y. Wang, Y. Sun, J. Kamei, K. I. Czernin, J. Radu, C. G. Tseng, H. R. A Supramolecular Approach for Preparation of Size-Controlled Nanoparticles.
Angew Chem Int Ed Engl.
2009;
48( 24):
4344-4348.
Kamei, K. Guo, S. Yu, Z. T. Takahashi, H. Gschweng, E. Suh, C. Wang, X. Tang, J. McLaughlin, J. Witte, O. N. Lee, K. B. Tseng, H. R. An integrated microfluidic culture device for quantitative analysis of human embryonic stem cells.
Lab Chip.
2009;
9( 4):
555-63.
Coti, K. K. Wang, Y. Lin, W. Y. Chen, C. C. Tak For Yu, Z. Liu, K. Shen, C. K. Selke, M. Yeh, A. Lu, W. Tseng, H. R. A dynamic micromixer for arbitrary control of disguised chemical selectivity.
Chem Commun (Camb).
2008;
( 29):
3426-8.
Sui, G. Lee, C. C. Kamei, K. Li, H. J. Wang, J. Y. Wang, J. Herschman, H. R. Tseng, H. R. A microfluidic platform for sequential ligand labeling and cell binding analysis.
Biomed Microdevices.
2007;
9( 3):
301-5.
Green JE, Choi JW, Boukai A, Bunimovich Y, Johnston-Halperin E, DeIonno E, Luo Y, Sheriff BA, Xu K, Shin YS, Tseng HR, Stoddart JF, Heath JR A 160-Kilobit Molecular Electronic Memory Patterned at 1011 Bits per Square Centimeter.
Nature.
2007;
445:
414-417.
Sui G, Tseng HR Reactions in Hand.
Nano Today .
2006;
1:
6-7.
Clark, A. P. Cadby, A. J. Shen, C. K. Rubin, Y. Tolbert, S. H. Synthesis and self-assembly of an amphiphilic poly(phenylene ethynylene) ionomer.
J Phys Chem B.
2006;
110( 44):
22088-96.
Sui G, Wang J, Lee CC, Lee SP, Leyton JV, Wu AM, Tseng HR Solution-Phase Surface Modification in Intact Poly(dimethylsiloxane) Microfluidic Channels.
Anal. Chem..
2006;
78:
5543-5551.
Lee CC, Sui G, Elizarov A, Shu CJ, Shin YS, Doole AN, Stout D, Witte ON, Kolb HC, Satyamurthy N, Heath JR, Phelps ME, Quake SR, Tseng HR MultiStep Synthesis of a Radiolabeled Imaging Probe using Integrated Microfluidics.
Science.
2005;
310:
1793-1796.
Alam, M. M. Wang, J. Guo, Y. Lee, S. P. Tseng, H. R. Electrolyte-gated transistors based on conducting polymer nanowire junction arrays.
J Phys Chem B.
2005;
109( 26):
12777-84.
Liu Y, Flood AH, Bonvallet PA, Vignon SA, Northrop BH, Tseng HR, Jeppesen JO, Huang TJ, Brough B, Baller M, Magonov S, Solares SD, Goddard WA, Ho CM, Stoddart JF Linear artificial molecular muscles..
Journal of the American Chemical Society. .
2005;
127(27):
9745-59.
Wang J, Chan S, Carlson SS, Luo Y, Ge G, Ries RS, Heath JR, Tseng HR "Electrochemically Fabricated Polyaniline Nanoframework Electrode Junctions That Function as Resistive Sensors".
Nano Lett. .
2004;
4:
1693-1697.
Huang TJ, Brough B, Ho CM, Liu Y, Flood AH, Bonvallet PA, Tseng HR, Stoddart JF, Baller M, Magonov M "A Nanomechanical Device Based on Linear Molecular Motors".
Appl. Phys. Lett. .
2004;
85:
5391-5393.
Marchioni F, Venturi M, Ceroni P, Balzani V, Belohradsky M, Elizarov AM, Tseng HR, Stoddart JF Complete charge pooling is prevented in viologen-based dendrimers by self-protection..
Chemistry (Weinheim an der Bergstrasse, Germany) .
2004;
10(24):
6361-8.
Tseng HR, Wu D, Fang NX, Zhang X, Stoddart JF The Metastability of an Electrochemical Controlled Nanoscale Machine on Gold Surfaces.
ChemPhysChem.
2004;
(5):
111-116.
Yu H, Luo Y, Beverley K, Tseng HR, Stoddart JF, Heath JR The Molecule / Electrode Interfaces in Single-Molecule Transistors.
Angew. Chem. Int. Ed..
2003;
(42):
5706-5711.
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