All Faculty

Jennifer Murphy

Member, Molecular Pharmacology GPB Home Area, Physics & Biology in Medicine GPB Home Area
Faculty, Crump Institute for Molecular Imaging, Molecular & Medical Pharmacology

Modern methods for the construction of carbon-fluorine bonds

Email Address:
Work Email Address:

Laboratory Address:
CNSI 4310, Crump Institute for Molecular Imaging
Office Address:
CNSI 4321, Crump Institute for Molecular Imaging

Phone Numbers:
(310) 825-7548

Selected Publications:

Anthony R. Mazzotti, Michael G. Campbell, Pingping Tang, Jennifer M. Murphy, Tobias Ritter Palladium(III)-catalyzed fluorination of arylboronic acid derivatives. Journal of the American Chemical Society 2013; 135(38): 14012-14015.
Jennifer M. Murphy; Amanda L. Armijo; Julian Nomme; Chi Hang Lee; Quentin A. Smith; Zheng Li; Dean O. Campbell; Hsiang-I Liao; David A. Nathanson; Wayne R. Austin; Jason T. Lee; Ryan Darvish; Liu Wei; Jue Wang; Ying Su; Robert Damoiseaux; Saman Sadeghi; Michael E. Phelps; Harvey R. Herschman; Johannes Czernin; Anastassia N. Alexandrova; Michael E. Jung; Arnon Lavie; Caius G. Radu Development of new deoxycytidine kinase inhibitors and noninvasive in vivo evaluation using positron emission tomography. Journal of Medicinal Chemistry 2013; 56(17): 6696-6708.
David A. Nathanson; Amanda L. Armijo; Michelle Tom; Zheng Li; Elizabeth Dimitrova; Wayne R. Austin; Julian Nomme; Dean O. Campbell; Lisa Ta; Thuc M. Le; Jason T. Lee; Ryan Darvish; Ari Gordin; Liu Wei; Hsiang-I Liao; Moses Wilks; Colette Martin; Saman Sadeghi; Jennifer M. Murphy; Nidal Boulos; Michael E. Phelps; Johannes Czernin; Arnon Lavie; Caius G. Radu Co-targeting of convergent nucleotide biosynthetic pathways for leukemia eradication. J. Exp. Med 2014; 211: 473-486.
Julian Nomme; Jennifer M. Murphy; Ying Su; Natasha D. Sansone; Amanda L. Armijo; Steven T. Olson; Caius G. Radu; Arnon Lavie Structural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity determining moieties of the molecules. Acta Cryst 2014; D70: 68-78.
Michael E. Jung, Jennifer M. Murphy Functional group selectivity in reactions of epoxides with tungsten hexachloride. Tetrahedron Letters 2007; 48(47): 8388-8391.
Lazari, M.; Lyashchenko, S.K.; Burnazi, E.M.; Lewis, J.S.; van Dam, R.M.; Murphy, J.M. Fully-automated synthesis of 16β-18F-Fluoro-5α-dihydrotestosterone (18F-FDHT) on the ELIXYS radiosynthesizer. Appl. Radiat. Isot. 2015; 103: 9-14.
Narayanam, M.K.; Liang, Y.; Houk, K.N.; Murphy, J.M. Discovery of new mutually orthogonal bioorthogonal cycloaddition pairs through computational screening. Chem. Sci. 2016; 7: 1257-1261.
Gamache, R.F; Waldmann, C.; Murphy, J.M. Copper-mediated oxidative fluorination of aryl stannanes with fluoride. Org. Lett. 2016; 18: 4522-4525.
Hoover, A.J.; Lazari, M.; Ren, H.; Narayanam, M.K.; Murphy, J.M.; van Dam, R.M.; Hooker, J.M.; Ritter, T. A transmetalation reaction enables the synthesis of [18F]5-Fluorouracil from [18F]Fluoride for Human PET Imaging. Organometallics 2016; 35: 1008-1014.
Narayanam, M.K.; Ma, G.; Champagne, P.A.; Houk, K.N.; Murphy, J.M. Synthesis of [18F]fluorarenes via nucleophilic radiofluorination of N-arylsydnones. Angew. Chem. Int. Ed. 2017; 56: 13006-13010.
Collins, J.; Waldmann, C.M.; Drake, C.; Slavik, R.; Ha, N.S.; Sergeev, M.; Lazari, M.; Shen, B.; Chin, F.T.; Moore, M.; Sadeghi, S.; Phelps, M.E.; Murphy, J.M.; van Dam, R.M. Production of diverse PET probes with limited resources: 24 18F-labeled compounds prepared with a single radiosynthesizer. Proc. Natl. Acad. Sci. U.S.A. 2017; 114: 11309-11314.
Tao, H.; Liu, F.; Zheng, R.; Shao, Z.; Zou, L.; Cao, Y.; Murphy, J.M.; Houk, K.N.; Liang, Y. Origins of halogen effects in bioorthogonal sydnone cycloadditions. Chem. Commun 2018; 54: 5082-5085.
Levandowski, B.J.; Gamache, R.F.; Murphy, J.M.*; Houk, K.N.* Readily accessible ambiphilic cyclopentadienes for bioorthogonal labeling. J. Am. Chem. Soc 2018; 140: 6426-6431.